Over one year into COVID-19 pandemic, efforts are still needed to support the health care and related needs of the world’s children and their families. Disruption of essential services across MNCH has impacted millions of lives around the world. However, maintaining quality essential care is critical. To facilitate recovery efforts in countries, UNICEF in collaboration with International Pediatric Association (IPA) and USAID developed a technical brief “DO NO HARM – Maternal, Newborn and Infant Care during COVID-19”. The brief summarizes current evidence and guidance for maintaining safe and effective care across the spectrum of maternal, newborn and infant care and re-emphasizes key infection prevention and control (IPC) principles for safe oxygen delivery.