Given the impact of misinformation on the success of vaccination programs across the world, UNICEF, First Draft, Yale Institute for Global Health, and PGP (The Public Good Projects) have partnered to create the Vaccine Misinformation Management Field Guide. This guide aims to help organizations address the global infodemic through the development of strategic and well-coordinated national action plans to rapidly counter vaccine misinformation and build demand for vaccination that are informed by social listening. This is a useful tool to help countries develop a strategy to counter misinformation related to COVID-19 vaccine introduction.