The Framework for Health Systems Strengthening and COVID-19 vaccine delivery and program implementation aims to support governments and partners to identity the opportunities to strengthen health and other sectoral systems when developing and implementing the workplan for COVID-19 vaccine. The proposed actions consider health-system-wide and gender responsive approaches, which include multi-sectoral participation and integrated people-centered health service delivery. The framework offers a menu of actions, considering criteria for health system strengthening for designing, selecting and implementing programs