Across the world, humanitarian crises are becoming more frequent, complex and persistent, affecting more children than ever before. While encouraging progress has been achieved in improving child survival and wellbeing during the last several decades, conflicts, political and economic instability, climate change and natural disasters, displacements and public health emergencies have threatened hard-fought development gains and, in many places, reversed them. This document provides an overview of the health issues that children face in humanitarian settings, UNICEF's response and programmatic priorities, and the way forward.